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It is important to note that although no specific studies have been performed on synovial myofibroblasts in OA, integrins containing the v-, 5-, and 1-subunit are increased in the synovial lining layer in OA (72)

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Was the result independently replicated

Its essential to differentiate between self-initiated changes (where the individual decides to modify their own routine) versus externally imposed changes (those that are unexpected or forced upon them)